Fig. 1

Dynamics of EV and VM formation during tumor development. a Representative images of H22 tumor tissues. b, c Comparison of spatial differentiation between endothelial vessels and vasculogenic mimicry under CD31 immunohistochemistry-PAS double staining (200×). d Endothelial vessels and vasculogenic mimicry density after tumor inoculation. e, f Dynamics of body weight change and tumor growth after tumor inoculation. Data were represented as mean ± S.D. n = 40