Fig. 3

Vesicles size profiling and characterization of the vesicular DNA. Size distribution from Dynamic Light Scattering analysis of plasma vesicles isolated from stroke, multiple sclerosis, Parkinson’s disease patients and from healthy controls. Each graph is representative of three measurements and illustrates size (nm) versus intensity (relative frequency of each size range among the entire population of the isolated vesicles) (a). Size profile determination of the DNA extracted from patients and controls plasma-isolated vesicles preparations using Bioanalyzer System. The electropherograms show sizes spectrum in nucleotides (nt) and fluorescence intensity (FU) of the DNA contained in the vesicles collected from neurological patients and from healthy volunteers. Each individual graph represents one of three experiments with similar results (b)