Fig. 6

BPTF is positively regulated by TFAP4 and activates the downstream PI3K/AKT pathway. A PCR of the enrolled children with NB revealed a positive association between BPTF and TFAP4 (n = 95). r = 0.272, P = 0.008, by Spearman’s correlation coefficient. B-C Representative expression levels of BPTF, p-AKT, AKT, N-cadherin, E-cadherin and GAPGH in the SK-N-BE (2) (B) and SH-SY5Y cells (C) transfected with siNC and siTFAP4. D-E Representative expression levels of BPTF, p-AKT, AKT, N-cadherin, E-cadherin and GAPGH in the SK-N-BE (2) (D) and SH-SY5Y cells (E) cell transfected with Vec and HA-TFAP4 plasmid. The data are representative of at least three independent experiments