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Table 1 Lung oxidant and anti-oxidant levels in different studied groups

From: Investigating the Anti-inflammatory Effect of Quinoline Derivative: N1-(5-methyl-5H-indolo[2,3-b]quinolin-11-yl)benzene-1,4-diamine Hydrochloride Loaded Soluble Starch Nanoparticles Against Methotrexate-induced Inflammation in Experimental Model

Parameters

GSH

(mg / g tissue)

MDA

(nmol /g tissue)

NO

(μmol / g tissue)

AOPP

(ng/g tissue)

Groups

Control

Mean ± SE

30.09 ± .87

39.8 ± 1.5

7.1 ± .37

13.5 ± .25

MTX

Mean ± SE

% of change from control group

13.41a ± .15

-55.4%

249.1a ± 1.7

525.8%

27.6a ± .55

288.7%

37.1a ± .58

174.8%

MTX + StNPs

Mean ± SE

% of change from MTX group

14.64a ± .25

9.1%

213.2a,b ± 1.4

-14.4%

21.5a,b ± .58

-22.1%

25.7a,b ± .25

-30.72%

MTX + StNPs-1

Mean ± SE

% of change from MTX group

17.19a,b,c ± .46

28.1%

180a,b,c ± 2.6

-27.7%

17.8a,b,c ± .45

-35.5%

22.6a,b,c ± .54

-39%

MTX + StNPs-2

Mean ± SE

% of change from MTX group

19.96a,b,c ± .34

48.8%

119.9a,b,c ± 2.2

-51.8%

15.3a,b,c ± .53

-44.5%

20.5a,b,c ± .46

-44.7%

MTX + StNPs-3

Mean ± SE

% of change from MTX group

23.44a,b,c ± .38

74.7%

82.7a,b,c ± 1.9

-66.8%

10.8a,b,c ± .25

-60.8%

18a,b,c ± .49

-51.4%

  1. Pa: significance compared to the control group, Pb: significance compared to MTX group, Pc: significance compared to MTX + StNPs group