Investigating the Anti-inflammatory Effect of Quinoline Derivative: N1-(5-methyl-5H-indolo[2,3-b]quinolin-11-yl)benzene-1,4-diamine Hydrochloride Loaded Soluble Starch Nanoparticles Against Methotrexate-induced Inflammation in Experimental Model

Table 4 Liver inflammatory markers in different studied groups

Parameters	MMP-9 (ng/mg tissue)	IL-1β (pg/mg tissue)	NF-kB (pg/mg tissue)
Groups	MMP-9 (ng/mg tissue)	IL-1β (pg/mg tissue)	NF-kB (pg/mg tissue)
Control
Mean ± SE	38.5 ± .91	17.2 ± .54	99.2 ± 4.1
MTX
Mean ± SE % of change from control group	103.6^a ± 2.1 169%	44^a ± .82 155.8%	255.4^a ± 1.8 157.4%
MTX + StNPs
Mean ± SE % of change from MTX group	92.7^a,b ± 1.1 -10.5%	36.8^a,b ± .76 -16.3%	241.9^a,b ± 1.1 -5.2%
MTX + StNPs-1
Mean ± SE % of change from MTX group	81.9^a,b,c ± 1.2 -20.9%	28.8^a,b,c ± .80 -34.5%	234.5^a,b,c ± 1.3 -8.1%
MTX + StNPs-2
Mean ± SE % of change from MTX group	68^a,b,c ± 1.5 -34.3%	24.4^a,b,c ± .48 -44.5%	213.6^a,b,c ± 1.7 -16.3%
MTX + StNPs-3
Mean ± SE % of change from MTX group	52.2^a,b,c ± 1.0 -49.6%	21^a,b,c ± .40 -52.2%	168^a,b,c ± 2.2 -34.2%

P^a: significance compared to the control group, P^b: significance compared to MTX group, P^c: significance compared to MTX + StNPs group

ISSN: 1480-9222