Fig. 2

Schematic Representation of Methodological Approaches in Extracellular Vesicle Loading for Functional Uptake in Target Cells. Lipid bilayer-delimited particles (EVs) serve as an effective novel drug delivery system for endless pharmaceutical compounds, including miRNAs. Thus, the method of incorporation for enriching miRNA cargoes into EVs can be segmented into two main sub-types: passive (donor cell manipulation) and active (direct EV alterations) loading methods