Skip to main content

Table 1 Role of exosomes in risk and etiology of cancer

From: Role of Exosomes in Cancer and Aptamer-Modified Exosomes as a Promising Platform for Cancer Targeted Therapy

Exosomes source

Cargo

Key findings

Reference

Breast milk

miR-148a

Target DNMT1 to influence risk of cancer

[52,53,54]

Serum of patient

CagA

Establish a possible link between infection of H. pylori and development of GC

[66]

EBV-infected NPC cell

LMP1 and EBV-miRNAs

Activate oncogenic ERK and AKT signaling pathways in uninfected recipient cells

[70, 71]

HPV-positive cervical cancer cell

Viral DNA and transcripts

Provide evidence of exosome-mediated transfer of viral genetic information

[78, 79]

  1. DNMT1: DNA methyltransferase 1; GC: gastric cancer; EBV: Epstein–Barr virus; LMP1: latent membrane protein 1; NPC: nasopharyngeal carcinoma; HPV: human papillomavirus