Table 2 Role of exosomes in initiation of cancer
Exosomes source | Cargo | Key finding | Reference |
|---|---|---|---|
PC cell | Undetermined | Initiate transformation of NIH/3T3 cells by inducing random mutations | [80] |
GC cell | miR-15b-3p | Induce malignant transformation of normal gastric mucosa epithelium cell | [81] |
BC cell | miRNAs and RLC | Induce transcriptome alterations in recipient nontumorigenic epithelial cell and transformation | [82] |
Cancer cell | LncRNA H19 | Regulate CSCs | Reviewed in [88] |
CAFs | miR-146a-5p | Promote bladder cancer stemness by generating a favorable niche | [89] |
OSCC cell | THBS1 | Activate M1-like TAMs to promote malignant migration in OSCC | [93] |
M1-like TAMs | IL-6 | Cascade a mesenchymal/stem-like phenotype of OSCC | [94] |