Table 6 Established primate models of tendon defect
Tendon(s) | Types of model | Defect procedure | Repair procedure | Timepoints | Objective(s) | Comments |
|---|---|---|---|---|---|---|
Supraspinatus tendon | Acute | Unilateral complete division | Not specified | Week 4, 8, 12, 16 | Establishment of a model for supraspinatus tendon repair in baboons [96]. | Advantages:  1. High anatomical similarity to humans.  2. High physiological similarity to humans.  3. Produce joint loads to the rotator cuff that are comparable in magnitude to those experienced by humans. Disadvantages:  1. High cost.  2. Complexity of management.  3. Challenging to justify ethical approval. |
Unilateral excision | Not specified | 3, 6 months | The repair effect and immune response of a non-crosslinked porcine dermal extracellular matrix graft [97]. |