Fig. 6

The level of maturation of the differentiated astrocytes from iPSCs. A Heatmap showing basemean expression profile of the 54 marker genes from hiPSC-derived astrocytes, primary astrocytes (Zhang_AA [25]), hiPSCs derived astrocytes (TCW_A [20], Perriot_A [23]), hPSC-derived astrocytes (Bradley [54]), NPC-derived astrocytes (Magistri_A [22]) and fetal astrocytes (Zhang_FA [25], Crowe_FA [53]). B Heatmap showing the percentage of generated astrocytic cultures sharing the expression signatures with the prefrontal cortex single-nucleus transcriptomic data [46]. C Heatmap showing basemean expression profile of the core genes related to FBS reactive-astrocytes genes signature according to study of Magistri et al. [22]. A—Astrocytes, AA – Adult Astrocytes, FA – Fetal Astrocytes, VFA—Ventral Forebrain Astrocytes, DFA—Dorsal Forebrain Astrocytes, VSC—Ventral Spinal Cord Astrocytes, DSC—Dorsal Spinal Cord Astrocytes