Fig. 5

Comparison of ChIP-seq datasets between lymphoid tissue and sorted cells. A, Representative IGV tracks of H3K27ac signals. Three B-cell-related genes (PAX5, BCL11A, and BANK1) were enriched in unsorted lymphoid tissue (AITL2) but were negatively enriched or slightly enriched in isolated CD3 + PD1 + cells. The enrichment of ICOS increased, whereas the enrichment of MYC decreased slightly after sorting. B, Comparison of SE numbers between unsorted tissue and the corresponding sorted samples of CD3 + PD1 + cells from the 3 nTFHL-AI lymphoid tissues. C, Venn diagram showing the common and separate SE numbers between unsorted tissue and the corresponding sorted CD3 + PD1 + cells from AITL1, AITL2 and AITL3. D, Hierarchical clustering of ChIP-seq datasets according to the identified SEs of 3 nTFHL-AI lymphoid tissues and the corresponding sorted CD3 + PD1 + lymphocytes