Table 2 Sensitivity analysis of the MR analysis results of exposures and outcomes
From: Therapeutic Targets for Gastric Cancer: Mendelian Randomization and Colocalization Analysis
Exposure | Outcome | Heterogeneity Test | Pleiotropy Test | |
|---|---|---|---|---|
Cochran’s Q Test (p Value) | Rucker’s Q Test (p Value) | Egger Intercept (p Value) | ||
IVW | MR-Egger | MR-Egger | ||
ANGPT2 | Gastric Cancer | 0.646881 | 0.488626 | 0.468085 |
ATRAID | Gastric Cancer | 0.765174 | 0.884322 | 0.764754 |
BPIFA2 | Gastric Cancer | 0.280085 | 0.467079 | 0.987072 |
CD6 | Gastric Cancer | 0.997511 | 0.878296 | 0.361428 |
CFHR2 | Gastric Cancer | 0.776952 | 0.774277 | 0.406042 |
CPQ | Gastric Cancer | 0.261885 | 0.368457 | 0.892255 |
FUT8 | Gastric Cancer | 0.589196 | 0.666585 | 0.706107 |
HCG22 | Gastric Cancer | 0.266907 | 0.351851 | 0.591431 |
IGLC2 | Gastric Cancer | 0.428328 | 0.670951 | 0.750529 |
LILRB1 | Gastric Cancer | 0.61599 | 0.736961 | 0.769432 |
LTB | Gastric Cancer | 0.772699 | 0.956961 | 0.957109 |
MATN3 | Gastric Cancer | 0.321582 | 0.293014 | 0.287343 |
NELL1 | Gastric Cancer | 0.315403 | 0.596285 | 0.898313 |
NMNAT1 | Gastric Cancer | 0.174267 | 0.281713 | 0.651083 |
PBLD | Gastric Cancer | 0.739318 | 0.801009 | 0.597319 |
PPCDC | Gastric Cancer | 0.708374 | 0.728443 | 0.515546 |
RGMA | Gastric Cancer | 0.753765 | 0.794314 | 0.536919 |
TLR3 | Gastric Cancer | 0.762386 | 0.783241 | 0.501658 |
TNFRSF10C | Gastric Cancer | 0.494343 | 0.443654 | 0.376672 |
TNFRSF11A | Gastric Cancer | 0.881754 | 0.827594 | 0.343796 |
TNFSF12 | Gastric Cancer | 0.273124 | 0.438927 | 0.796613 |